There is no cure for migraine. However, medications can treat the symptoms when they arise, and people can take steps to reduce the frequency and severity of episodes.


Pain relief and other types of medication can often help. Taking medication as soon as symptoms start may keep them from becoming severe.

Some over-the-counter pain relief medications that may benefit people with migraine include:

  • naproxen
  • ibuprofen
  • acetaminophen (Tylenol)

Other options include:

  • triptans, such as sumatriptan to help reverse the brain changes that cause migraine
  • antiemetics to manage any nausea and vomiting
  • gepants, which block a protein involved in inflammation and pain called calcitonin gene-related peptide (CGRP)
  • ditans, which interact with 5-HT1F receptors on the sensory nerves and blood vessels

It is important not to overuse medication, as doing so can cause a rebound headache. A healthcare provider can help a person determine how much of each medication is safe and effective.


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